1-Propionyl-lysergic acid diethylamide (commonly known as 1P-LSD or 1P-LAD) is a novel semi-synthetic psychedelic substance of the lysergamide chemical class that produces “classical psychedelic” effects reported to be near-identical with those of LSD when administered. Like ALD-52, it is principally theorized to act as a prodrug for LSD, not exerting any activity until it has been converted into LSD after entering the body, although there is ongoing speculation that it might possess some intrinsic activity in its own right.
The structural resemblance 1P-LSD shares with LSD suggests an extremely similar effect profile, with perhaps the only significant differences stemming from variations in the rate of absorption, duration, metabolism, and excretion of the compound (i.e. its pharmacokinetic factors). Due to the lack of research relating to this substance, all following discussion relating to its pharmacology is purely based on its structural and subjective effect similarities to LSD and other designer lysergamides.